What You Need to Know
The system relies on the adsorption of RGD peptides onto cellulose or soy protein scaffolds to promote integrin-mediated adhesion of myoblasts. Controlled perfusion delivers nutrients and shear stress, while cyclic stretch enhances sarcomere alignment and upregulates myosin heavy chain expression. The chemistry of the media, including IGF‑1, HGF, and insulin, drives proliferation and differentiation through MAPK and PI3K signaling pathways.
The Science
Primary Reaction
myoblast proliferation and differentiation into myotubes