Mesenchymal stem cell-secreted prostaglandin E2 ameliorates acute liver failure via attenuation of cell death and regulation of macrophage polarization
Jinglin Wang, Yang Liu, Haoran Ding, Xiaolei Shi, Haozhen Ren
Stem Cell Research & Therapy
Abstract
Our results indicate that PGE<sub>2</sub> might be a novel important mediator of MSC in treating ALF, which is through inhibiting the liver inflammatory response and hepatocyte death.
Concepts
Mesenchymal stem cellCell biologyStem cellProstaglandin E2CellProgrammed cell deathMacrophage polarizationChemistry