The Human Milk Oligosaccharides 3‐FL, Lacto‐N‐Neotetraose, and LDFT Attenuate Tumor Necrosis Factor‐α Induced Inflammation in Fetal Intestinal Epithelial Cells In Vitro through Shedding or Interacting with Tumor Necrosis Factor Receptor 1
Lianghui Cheng, Chunli Kong, Wenjia Wang, André Groeneveld, Arjen Nauta, Matthew R. Groves +2 more
Molecular Nutrition & Food Research
Abstract
The findings indicate that specific hMO types attenuate TNF-α induced inflammation in fetal gut epithelial cells through TNFR1 in a hMO structure-dependent fashion suggest possibilities to apply hMOs in management of TNF-α dependent diseases.
Extracted Claims
1 claim extracted from this paper into the knowledge graph
compound_effect100% confidence
Human Milk Oligosaccharides (3‐FL, Lacto‐N‐Neotetraose, LDFT) attenuate TNF-α induced inflammation
“The findings indicate that specific hMO types attenuate TNF-α induced inflammation in fetal gut epithelial cells through TNFR1 in a hMO structure-dependent fashion suggest possibilities to apply hMOs ...”
Concepts
Tumor necrosis factor alphaInflammationNecrosisImmunologyMicroscale thermophoresisEctodomainSecretionReceptor