A systematic review on ethnopharmacology, phytochemistry and pharmacological aspects of Thymus vulgaris Linn.
Shashank M. Patil, Ramith Ramu, Prithvi S. Shirahatti, Chandan Shivamallu, Raghavendra G. Amachawadi
Heliyon
Abstract
<i>Thymus vulgaris</i> Linn. is a medicinal and culinary herb from the Southern European region known for its anti-infective, cardioprotective, gastroprotective, anti-inflammatory, and immunomodulatory activities since the Egyptian era. The reported pharmacological activities of <i>T. vulgaris</i> L. include antibacterial, antioxidant, anti-inflammatory, antiviral, and anti-cancerous activities. In this review, a comprehensive approach is put forth to scrutinize and report the available data on phytochemistry, ethnopharmacology, pharmacology, and toxicology of the plant. The different extracts and essential oil obtained from the plant have been assessed and reported to treat ailments like microbial infections, inflammation, non-communicable diseases like cancer, and sexually transmitted diseases like HIV-1 and Herpes. The literature review has also indicated the use of volatile oils, phenolic acids, terpenoids, flavonoids, saponins, steroids, tannins, alkaloids, and polysaccharides in pharmacotherapy. Applications of these compounds including antidiabetic, anti-Alzheimer's, cardio, neuro and hepatoprotective, anti-osteoporosis, sedative, immunomodulatory, antioxidant, anti-tyrosinase, antispasmodic, antinociceptive, gastroprotective, anticonvulsant, antihypertensive, antidepressant, anti-amnesia, and anti-helminthic activities have been mentioned. Further, based on research gaps, recommendations have been provided to evaluate <i>T. vulgaris</i> L. systematically to develop plant-based drugs, nutraceuticals, and to evaluate their clinical efficiency and safety.
Extracted Claims
3 claims extracted from this paper into the knowledge graph
Thymus vulgaris Linn. has anti-infective, cardioprotective, gastroprotective, anti-inflammatory, and immunomodulatory activities
“is known for its anti-infective, cardioprotective, gastroprotective, anti-inflammatory, and immunomodulatory activities since the Egyptian era.”
volatile oils, phenolic acids, terpenoids, flavonoids, saponins, steroids, tannins, alkaloids, and polysaccharides are used in pharmacotherapy
“The literature review has also indicated the use of volatile oils, phenolic acids, terpenoids, flavonoids, saponins, steroids, tannins, alkaloids, and polysaccharides in pharmacotherapy.”
Thymus vulgaris Linn. has antibacterial, antioxidant, anti-inflammatory, antiviral, and anti-cancerous activities
“The reported pharmacological activities of T. vulgaris L. include antibacterial, antioxidant, anti-inflammatory, antiviral, and anti-cancerous activities.”