ZIP10 drives osteosarcoma proliferation and chemoresistance through ITGA10-mediated activation of the PI3K/AKT pathway
Hongyu Li, Xin Shen, Mengjun Ma, Wenzhou Liu, Wen Yang, Peng Wang +8 more
Journal of Experimental & Clinical Cancer Research
Abstract
We demonstrate that ZIP10 drives OS proliferation and chemoresistance through ITGA10-mediated activation of the PI3K/AKT pathway, which might serve as a target for OS treatment.
Concepts
PI3K/AKT/mTOR pathwayProtein kinase BCancer researchGene knockdownCREBOsteosarcomaCell growthCarcinogenesis