Chemoinformatics View on Bitter Taste Receptor Agonists in Food
Sebastian Bayer, Ariane Isabell Mayer, Gigliola Borgonovo, Gabriella Morini, Antonella Di Pizio, Angela Bassoli
Journal of Agricultural and Food Chemistry
Abstract
Food compounds with a bitter taste have a role in human health, both for their capability to influence food choice and preferences and for their possible systemic effect due to the modulation of extra-oral bitter taste receptors (TAS2Rs). Investigating the interaction of bitter food compounds with TAS2Rs is a key step to unravel their complex effects on health and to pave the way to rationally design new additives for food formulation or drugs. Here, we propose a collection of food bitter compounds, for which in vitro activity data against TAS2Rs are available. The patterns of TAS2R subtype-specific agonists were analyzed using scaffold decomposition and chemical space analysis, providing a detailed characterization of the associations between food bitter tastants and TAS2Rs.
Extracted Claims
1 claim extracted from this paper into the knowledge graph
bitter food compounds interact with bitter taste receptors (TAS2Rs)
“Investigating the interaction of bitter food compounds with TAS2Rs is a key step to unravel their complex effects on health and to pave the way to rationally design new additives for food formulation ...”