Antibiofilm and anticancer activities of unripe and ripe Azadirachta indica (neem) seed extracts
Kartik Chandra Guchhait, Tuhin Manna, Manas Barai, Monalisha Karmakar, Sourav Kumar Nandi, Debarati Jana +8 more
BMC Complementary Medicine and Therapies
Abstract
Methanolic extract of neem seeds could substantially inhibit and eradicate biofilm along with their potent antibacterial and anticancer activities. Both the extracts showed higher antibiofilm and antibacterial activity against S. aureus (gram-positive) than V. cholerae (gram-negative). Moreover, ripe seed extract showed higher antibiofilm and anticancer activity than unripe extracts.
Concepts
AzadirachtaEthidium bromideMinimum bactericidal concentrationMinimum inhibitory concentrationAntimicrobialAcridine orangeChemistryAntibacterial activity