The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension
Lance Benson, Yunmeng Liu, Xiangting Wang, Yunzhao Xiong, Sung W. Rhee, Yunping Guo +12 more
Circulation Research
Abstract
Our results identified the role of activated CD8Ts in contributing to increased sodium retention in DCTS through the IFNγ-PDL1 pathway. These findings provide a new mechanism for T cell involvement in the pathogenesis of hypertension and reveal novel therapeutic targets.