Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association data from over 114,000 UK Biobank participants
Maria Carolina Borges, Philip Haycock, Jie Zheng, Gibran Hemani, Michael V. Holmes, George Davey Smith +2 more
BMC Medicine
Abstract
We have conducted the largest GWAS of circulating PUFA to date and the most comprehensive Mendelian randomization analyses. Overall, our Mendelian randomization findings do not support a protective role of circulating PUFA concentration on the risk of CVDs. However, horizontal pleiotropy via lipoprotein-related traits could be a key source of bias in our analyses.
Concepts
Mendelian randomizationMedicinePolyunsaturated fatty acidDocosahexaenoic acidGenome-wide association studyInternal medicineLinoleic acidCoronary artery disease