Comprehensive Review of γ-Glutamyl Peptides (γ-GPs) and Their Effect on Inflammation Concerning Cardiovascular Health
Snigdha Guha, Kaustav Majumder
Journal of Agricultural and Food Chemistry
Abstract
γ-Glutamyl peptides (γ-GPs) are a group of peptides naturally found in various food sources. The unique γ-bond potentially enables them to resist gastrointestinal digestion and offers high stability <i>in vivo</i> with a longer half-life. In recent years, these peptides have caught researchers' attention due to their ability to impart kokumi taste and elicit various physiological functions <i>via</i> the allosteric activation of the calcium-sensing receptor (CaSR). This review discusses the various food sources of γ-glutamyl peptides, different synthesis modes, allosteric activation of CaSR for taste perception, and associated multiple biological functions they can exhibit, with a special emphasis on their role in modulating chronic inflammation concerning cardiovascular health.
Extracted Claims
3 claims extracted from this paper into the knowledge graph
γ-glutamyl peptides (γ-GPs) elicit kokumi taste
“These peptides have caught researchers' attention due to their ability to impart kokumi taste and elicit various physiological functions via the allosteric activation of the calcium-sensing receptor (...”
γ-glutamyl peptides (γ-GPs) resist gastrointestinal digestion
“The unique γ-bond potentially enables them to resist gastrointestinal digestion and offers high stability in vivo with a longer half-life.”
γ-glutamyl peptides (γ-GPs) elicit physiological functions
“These peptides have caught researchers' attention due to their ability to impart kokumi taste and elicit various physiological functions via the allosteric activation of the calcium-sensing receptor (...”