DC ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension
Ashley Pitzer, Fernando Elijovich, Cheryl L. Laffer, Lale A. Ertuğlu, Melis Sahinoz, Mohammad Saleem +13 more
Circulation Research
Abstract
These findings reveal a mechanistic link between ENaC, inflammation, and salt-sensitive hypertension involving NLRP3 inflammasome activation in APCs. APC activation via the NLRP3 inflammasome can serve as a potential diagnostic biomarker for salt sensitivity of blood pressure.
Concepts
InflammasomeEpithelial sodium channelProinflammatory cytokinePyrin domainCaspase 1ReceptorChemistry