Classification and Multifaceted Potential of Secondary Metabolites Produced by Bacillus subtilis Group: A Comprehensive Review
Sajid Iqbal, Farida Begum, Ali A. Rabaan, Mohammed Aljeldah, Basim R. Al Shammari, Abdulsalam Alawfi +3 more
Molecules
Abstract
Despite their remarkable biosynthetic potential, <i>Bacillus subtilis</i> have been widely overlooked. However, their capability to withstand harsh conditions (extreme temperature, Ultraviolet (UV) and γ-radiation, and dehydration) and the promiscuous metabolites they synthesize have created increased commercial interest in them as a therapeutic agent, a food preservative, and a plant-pathogen control agent. Nevertheless, the commercial-scale availability of these metabolites is constrained due to challenges in their accessibility via synthesis and low fermentation yields. In the context of this rising in interest, we comprehensively visualized the antimicrobial peptides produced by <i>B. subtilis</i> and highlighted their prospective applications in various industries. Moreover, we proposed and classified these metabolites produced by the <i>B. subtilis</i> group based on their biosynthetic pathways and chemical structures. The biosynthetic pathway, bioactivity, and chemical structure are discussed in detail for each class. We believe that this review will spark a renewed interest in the often disregarded <i>B. subtilis</i> and its remarkable biosynthetic capabilities.
Extracted Claims
2 claims extracted from this paper into the knowledge graph
secondary metabolites produced by Bacillus subtilis
“However, their capability to withstand harsh conditions (extreme temperature, Ultraviolet (UV) and γ-radiation, and dehydration) and the promiscuous metabolites they synthesize have created increased ...”
fermentation has low yield secondary metabolites
“Nevertheless, the commercial-scale availability of these metabolites is constrained due to challenges in their accessibility via synthesis and low fermentation yields.”