Cupressus arizonica Greene: Phytochemical Profile and Cosmeceutical and Dermatological Properties of Its Leaf Extracts
Nora Tawfeek, Eman Fikry, Ismail Mahdi, Melvin Adhiambo Ochieng, Widad Ben Bakrim, Noamane Taarji +2 more
Molecules
Abstract
For many decades, natural resources have traditionally been employed in skin care. Here, we explored the phytochemical profile of the aqueous and ethanolic leaf extracts of <i>Cupressus arizonica</i> Greene and assessed their antioxidant, antiaging and antibacterial activities in vitro. Liquid chromatography-mass spectrometry (LC-MS/MS) analysis led to the tentative identification of 67 compounds consisting mainly of phenolic and fatty acids, diterpene acids, proanthocyanidins and flavonoid and biflavonoid glycosides. The aqueous extract demonstrated substantial in vitro antioxidant potential at FRAP and DPPH assays and inhibited the four target enzymes (collagenase, elastase, tyrosinase, and hyaluronidase) engaged in skin remodeling and aging with IC<sub>50</sub> values close to those of the standard drugs. Moreover, the aqueous extract at 25 mg/mL suppressed biofilm formation by <i>Pseudomonas aeruginosa</i>, a bacterial pathogen causing common skin manifestations, and decreased its swarming and swimming motilities. In conclusion, <i>C. arizonica</i> leaves can be considered a promising candidate for potential application in skin aging.
Extracted Claims
3 claims extracted from this paper into the knowledge graph
aqueous extract of Cupressus arizonica demonstrated substantial in vitro antioxidant potential
“The aqueous extract demonstrated substantial in vitro antioxidant potential at FRAP and DPPH assays”
aqueous extract of Cupressus arizonica suppressed biofilm formation
“The aqueous extract at 25 mg/mL suppressed biofilm formation by Pseudomonas aeruginosa, a bacterial pathogen causing common skin manifestations, and decreased its swarming and swimming motilities.”
aqueous extract of Cupressus arizonica inhibited target enzymes
“The aqueous extract inhibited the four target enzymes (collagenase, elastase, tyrosinase, and hyaluronidase) engaged in skin remodeling and aging with IC50 values close to those of the standard drugs.”