Gut Bacteria Involved in Ellagic Acid Metabolism To Yield Human Urolithin Metabotypes Revealed
Carlos E. Iglesias‐Aguirre, Rocío Garcı́a-Villalba, David Beltrán, María Dolores Frutos-Lisón, Juan Carlos Espı́n, Francisco A. Tómas‐Barberán +1 more
Journal of Agricultural and Food Chemistry
Abstract
We aimed to elucidate the gut bacteria that characterize the human urolithin metabotypes A and B (UM-A and UM-B). We report here a new bacterium isolated from the feces of a healthy woman, capable of producing the final metabolites urolithins A and B and different intermediates. Besides, we describe two gut bacterial co-cultures that reproduced the urolithin formation pathways upon in vitro fermentation of both UM-A and UM-B. This is the first time that the capacity of pure strains to metabolize ellagic acid cooperatively to yield urolithin profiles associated with UM-A and UM-B has been demonstrated. The urolithin-producing bacteria described herein could have potential as novel probiotics and in the industrial manufacture of bioactive urolithins to develop new ingredients, beverages, nutraceuticals, pharmaceuticals, and (or) functional foods. This is especially relevant in UM-0 individuals since they cannot produce bioactive urolithins.
Extracted Claims
5 claims extracted from this paper into the knowledge graph
urolithin-producing bacteria are relevant in UM-0 individuals
“This is especially relevant in UM-0 individuals since they cannot produce bioactive urolithins”
urolithin-producing bacteria have potential as novel probiotics and in the industrial manufacture of bioactive urolithins
“The urolithin-producing bacteria described herein could have potential as novel probiotics and in the industrial manufacture of bioactive urolithins”
gut bacterial co-cultures reproduce urolithin formation pathways
“we describe two gut bacterial co-cultures that reproduced the urolithin formation pathways upon in vitro fermentation of both UM-A and UM-B”