Urolithin A Produced by Novel Microbial Fermentation Possesses Anti-aging Effects by Improving Mitophagy and Reducing Reactive Oxygen Species in <i>Caenorhabditis elegans</i>
Mengwei Zhang, Shumao Cui, Bingyong Mao, Qiuxiang Zhang, Jianxin Zhao, Xin Tang +1 more
Journal of Agricultural and Food Chemistry
Abstract
Urolithin, intestinal microbiota metabolites of ellagitannin-rich foods, exhibit anti-aging activities. However, urolithin A is significantly superior to other types of urolithin with regard to this anti-aging function. This study aimed to screen edible urolithin A-producing strains of bacteria and explore the corresponding anti-aging efficacy of fermented products produced by these strains using <i>Caenorhabditis elegans</i> as a model. Our results showed that the <i>Lactobacillus plantarum</i> strains CCFM1286, CCFM1290, and CCFM1291 converted ellagitannin to produce urolithin A; the corresponding yields of urolithin A from these strains were 15.90 ± 1.46, 24.70 ± 0.82, and 32.01 ± 0.97 μM, respectively. Furthermore, it was found that the pomegranate juice extracts fermented by the CCFM1286, CCFM1290, and CCFM1291 strains of <i>L. plantarum</i> could extend lifespan by 26.04 ± 0.12, 32.05 ± 0.14, and 46.33 ± 0.12%, respectively, by improving mitochondrial function and/or reducing reactive oxygen species levels. These findings highlight the potential application of this fermentation in the subsequent development of anti-aging products.
Extracted Claims
2 claims extracted from this paper into the knowledge graph
pomegranate juice extracts fermented by CCFM1286, CCFM1290, and CCFM1291 strains of L. plantarum extend lifespan Caenorhabditis elegans
“Furthermore, it was found that the pomegranate juice extracts fermented by the CCFM1286, CCFM1290, and CCFM1291 strains of L. plantarum could extend lifespan by 26.04 ± 0.12, 32.05 ± 0.14, and 46.33 ±...”
Lactobacillus plantarum strains CCFM1286, CCFM1290, and CCFM1291 convert ellagitannin to produce urolithin A
“Our results showed that the Lactobacillus plantarum strains CCFM1286, CCFM1290, and CCFM1291 converted ellagitannin to produce urolithin A; the corresponding yields of urolithin A from these strains w...”