A systematically biosynthetic investigation of lactic acid bacteria reveals diverse antagonistic bacteriocins that potentially shape the human microbiome
Dengwei Zhang, Jian Zhang, Shanthini Kalimuthu, Jing Liu, Zhi‐Man Song, Bei‐Bei He +5 more
Microbiome
Abstract
Our study systematically investigates LAB biosynthetic potential and their profiles in the human microbiome, linking them to the antagonistic contributions to microbiome homeostasis via omics analysis. These discoveries of the diverse and prevalent antagonistic SMs are expected to stimulate the mechanism study of LAB's protective roles for the microbiome and host, highlighting the potential of LAB and their bacteriocins as therapeutic alternatives. Video Abstract.
Concepts
BiologyBacteriocinMicrobiomeMicrobial ecologyBacteriaLactic acidMedical microbiologyMicrobiology