Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions
Yujun Hou, Xixia Chu, Jae Hyeon Park, Qing Zhu, Mansoor Hussain, Zhiquan Li +7 more
Alzheimer s & Dementia
Abstract
Long-term urolithin A (UA) treatment improved learning, memory, and olfactory function in Alzheimer's disease (AD) mice. UA restored lysosomal functions in part by regulating cathepsin Z (Ctsz) protein. UA modulates immune responses and AD-specific pathophysiological pathways.
Concepts
MitophagyCognitionDiseaseNeuroscience