The impact of copper on bone metabolism
Zihan Zhang, Huixue Tang, Tingting Du, Di Yang
Journal of Orthopaedic Translation
Abstract
Copper is an essential trace element for the human body. Abnormalities in copper metabolism can lead to bone defects, mainly by directly affecting the viability of osteoblasts and osteoclasts and their bone remodeling function, or indirectly regulating bone metabolism by influencing enzyme activities as cofactors. Copper ions released from biological materials can affect osteoblasts and osteoclasts, either directly or indirectly by modulating the inflammatory response, oxidative stress, and rapamycin signaling. This review presents an overview of recent progress in the impact of copper on bone metabolism. <b>Translational potential of this article</b>: The impact of copper on bone metabolism can provide insights into clinical application of copper-containing supplements and biomaterials.
Extracted Claims
3 claims extracted from this paper into the knowledge graph
abnormalities in copper metabolism can lead to bone defects
“Abnormalities in copper metabolism can lead to bone defects, mainly by directly affecting the viability of osteoblasts and osteoclasts and their bone remodeling function, or indirectly regulating bone...”
copper is essential for human body
“Copper is an essential trace element for the human body.”
copper ions affect osteoblasts and osteoclasts
“Copper ions released from biological materials can affect osteoblasts and osteoclasts, either directly or indirectly by modulating the inflammatory response, oxidative stress, and rapamycin signaling.”