Protein Oxidation in Aging, Disease, and Oxidative Stress

Abstract

The demonstration that oxidatively modified forms of proteins accumulate during aging, oxidative stress, and in some pathological conditions has focused attention on physiological and non-physiological mechanisms for the generation of reactive oxygen species (ROS) 1The abbreviations used are: ROS, reactive oxygen species; MeSOX, methionine sulfoxide reductase; PN, peroxynitrite; GS, glutamine synthetase. 1The abbreviations used are: ROS, reactive oxygen species; MeSOX, methionine sulfoxide reductase; PN, peroxynitrite; GS, glutamine synthetase. and on the modification of biological molecules by various kinds of ROS. Basic principles that govern the oxidation of proteins by ROS were established in the pioneering studies of Swallow (1Swallow A.J. Swallow A.J. Radiation Chemistry of Organic C