High-throughput analysis of bisphenols in foods through covalent triazine polymer@dendritic fibrous nanosilica based thin-film microextraction coupled with high-performance liquid chromatography.

Abstract

Herein, we developed a high-throughput analytical platform that integrates thin-film microextraction (TFME) with high-performance liquid chromatography (HPLC), enabling efficient, precise, and sensitive detection of BPs in food samples. Covalent triazine polymer modified dendritic fibrous nanosilica (CTP@DFNS) composite was employed to prepare TFME coatings on the 96-blade-type extraction array. A standardized TFME workflow was developed using BPA, BPS, and BPF as targets. The TFME-HPLC approach displayed a wide linear range (0.5-1000 ng mL-1), high sensitivity (limits of detection from 0.04 to 0.17 ng mL-1) and good precision (RSDs below 6.9%). This method successfully detected BPs in boxed milk and canned foods, with spiked recoveries ranging from 85.1% to 110%, and RSDs below 5.7%. More prominently, this approach allows parallel pretreating 96 samples within 120 min, with an average time of 1.3 min per sample. This significant improvement in efficiency makes the method highly suitable for BPs analysis in large-scale food samples.